BGS Career Development
Making It Count!
Our group is interested in comparative analyses of normal lymphocyte development and malignant transformation towards leukemia. Our research involves experiments with primary human leukemia cells, leukemia and stem cell transplantation models, mouse genetics, gene editing, genetic biosensors of signal transduction, optogenetics, classical molecular and cell biology.
The main research interests in the Wu Lab are to understand the molecular mechanisms underlying the development, disease, and senescence of heart cells, and to develop potential therapeutic strategies to rectify pathogenesis and aging in the heart.
The main focus of the Sun lab is to delineate the physiological significance and underlying molecular mechanism of endoplasmic reticulum (ER)-associated protein degradation (ERAD) machinery in health and disease, with special focus on the regulation of liver homeostasis.
Our research focuses on identifying therapeutic strategies for the treatment of colorectal cancer. We are focused on targeting the unique vulnerabilities of cancer cells when they are in the drug tolerant state. Genetics, proteomics, transcriptomics, bioinformatics, Genome-wide CRISPR-Cas9 screening, biochemistry and molecular analyses of human cancer cells, mouse models and primary samples (including organoid culures) are used for our studies.
This postdoctoral project is a collaboration between a Drosophila neurogenetics lab and a biophysics trafficking lab. We are seeking a scholar to use multiple approaches including super-resolution imaging to study the transport and regulation of organelles in vivo, in neurons that are regenerating after injury.
We are seeking postdocs to study the mechanisms of genome instability, DNA repair and recombination. Our research interests range from the fundamental basic molecular mechanisms of DNA repair, recombination and replication in model organisms and human to diverse clinical applications including cancer therapeutics.