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Discussion with Leonard Hayflick, PhD, 2020 Distinguished Graduate Award Recipient

February 12, 2021 by Rebecca Lopez


Date: 03/01/2021
Time: 3:00 PM to 4:00 PM EST
Location: Virtual Event via BlueJeans Events
Registration: www.alumni.upenn.edu/dga2020hayflick

Leonard Hayflick, C’51, G’53, GR’56, a native Philadelphian, is currently Professor of Anatomy at the University of California, San Francisco. In 1962, as a member of the Wistar Institute and an assistant professor at the University of Pennsylvania Medical School, he discovered that cultured normal human cells had a limited ability to divide, overturning a 60-year-old dogma that all cells are potentially immortal. He interpreted his discovery to be aging at the cell level, which launched the modern era of aging research by redirecting its cause to intracellular events.

He also discovered that only cancer cells are immortal, which redirected research to how mortal normal human cells become immortal cancer cells.

Hayflick found that frozen normal human cells “remembered” their doubling level after thawing and discovered that the counting mechanism was located in the cells’ nucleus. The Nobel Prize was awarded to those who found the molecular mechanism for Hayflick’s phenomenological discoveries. Chromosome ends (telomeres) shorten at each cell division until their “Hayflick Limit” is reached, but cancer cell immortality was caused by an enzyme (telomerase) that synthesizes the molecules lost from their telomeres.

Hayflick also discovered that normal human cells replicated every human virus then known and developed the technology that enabled safer vaccines, thus benefiting more than one billion people. He invented an inverted microscope for cell culture work that is the father of all current inverted microscopes. It has been accessioned by the Smithsonian Institution along with packages of polio and rabies vaccines produced in his normal human cell strain WI-38.

Hayflick discovered that the cause of “walking pneumonia” was not a virus, as previously believed, but mycoplasmas, the smallest free living microorganisms known. He named the organism Mycoplasma pneumoniae that he grew on a unique medium and used worldwide.

Among Hayflick’s many honors is the John Scott Award from the City Council of Philadelphia, the oldest scientific award in the United States. It was established in 1816 to honor Benjamin Franklin.

Filed Under: Announcements Tagged With: Alumni, Alumni Speakers

Biotech & Informatics Career Panel – 2/22 at 2pm

February 12, 2021 by Rebecca Lopez


Curious about working in Industry? John Gregg, Van Truong, and GCB worked with Penn IBI to organize monthly Biotech & Informatics Career Panels. The first event takes place on Monday, February 22, 2021 from 2:00-3:30pm. Information on the speakers and the link to join via Zoom can be found in the attached flyer.

Save the dates for the other upcoming career panels – March 22 and April 22 from 2 – 3:30pm. More details to come.  

Filed Under: Announcements, Panels Tagged With: Career: Research (industry)

CHOP/Penn Center for Machine Learning in Urology

February 11, 2021 by Rebecca Lopez


Please note: BGS students interested in pursing an internship are required to obtain approval via the Career Internship Approval Form.

The Children’s Hospital of Philadelphia (CHOP)/Penn Center for Machine Learning in Urology will support a fully funded, paid 2-month summer research internship for 1 health professional (MD/DO) or biomedical graduate (MS/PhD) student per year. This intern will be fully integrated into the research team and larger CHOP/Penn research community. This will provide a support network that will lead to enhanced participation, learning, and growth over this short summer experience. The intern will be challenged with completing a mentored individual research project exploring the application of machine learning/artificial intelligence to the diagnosis and management of kidney stone disease. Faculty support will be provided by principle investigator Dr. Gregory Tasian with additional support from co-investigators Drs. Yong Fan and Justin Ziemba. We expect that this project will be submitted for presentation and publication. The internship program will run on campus at CHOP/Penn in Philadelphia for 8-weeks from Wednesday June 16, 2021-Wednesday August 11, 2021. A stipend of approximately $4,000 will be provided to cover the costs of living expenses while on campus. The application will include a short personal statement detailing how this internship will fit into future career plans and goals, a letter of reference from 1 current faculty member, and a CV. Interested applicants are encouraged to apply early, but the final deadline for applications will be March 31st 2021. All applications can be completed electronically at https://upenn.co1.qualtrics.com/jfe/form/SV_85GIShFCs28n25L. Please contact CHOP P20 Center PI Gregory Tasian, MD, MSCE at TasianG@chop.edu with any questions or for more information.

Filed Under: Announcements

Job Opening: Associate Principal Investigator at NBACC

February 11, 2021 by Rebecca Lopez

Image result for national biodefense analysis and countermeasures center


Interested candidates can apply to this opening here. The general careers page for the NBACC is here. If you have questions, please reach out to 2008 CAMB MVP alum Dr. Louis Altamura:

Louis Altamura, Ph.D.
Senior Principal Investigator – Virology
National Biodefense Analysis and Countermeasures Center (NBACC)
Operated by Battelle National Biodefense Institute (BNBI) for DHS

Full Time
Fort Detrick, MD, US

BACKGROUND

The National Biodefense Analysis and Countermeasures Center (NBACC) is a Department of Homeland Security (DHS) federal laboratory sponsored by the DHS Science and Technology Directorate and operated by the Battelle National Biodefense Institute, LLC (BNBI).

PRIMARY FUNCTION

Responsible for designing and executing multi-disciplinary research studies in the National Biological Threat Characterization Center (NBTCC) at the NBACC which address specific scientific questions of national significance in support of biodefense preparedness, response, and recovery. Research may include a range of topics related to the physical, biological, molecular and/or pathogenic properties of Biosafety Level 2, 3, and 4 viral agents. In particular, this position will involve maintaining and expanding NBTCC capabilities to execute research efforts involving molecular virology, eukaryotic genomic editing, sequencing and bioinformatics, and/or the study of systems level virus-host interactions.

MINIMUM REQUIRED QUALIFICATIONS

• Requires a PhD (or equivalent) in a scientific discipline or engineering, and a minimum of 2 years related experience; may include post-doctoral experience.
• Ability to work on problems of diverse scope in which analysis of data requires evaluation of identifiable factors, with expert knowledge of complex scientific principles and concepts.
• Proficiency and clarity of oral and written communications are essential.
• Exemplary organizational skills with a proven track record of working effectively both independently and as a team player.
• Knowledge or experience with biocontainment facilities and procedures, laboratory safety, biosurety, and decontamination desirable.
• Skills and experience to support laboratory activities and work in accordance with NBACC’s management system (e.g., ISO).
• Must be a citizen of the United States, able to obtain and maintain an interim secret clearance leading to a top secret clearance, suitability for DHS, a favorable adjudication of the Department of Justice (DoJ) for select agent access, and enrollment in the Personnel Reliability Program (PRP). Current clearance(s) desirable.
• Participation in the Immunization Program through Frederick Health Employer Solutions (FHES), is required.
• May be required to participate in NBACC’s alternative work and/or on-call schedule, dependent upon business needs.

MAJOR RESPONSIBILITIES

• Leverages subject matter expertise to maintain and expand NBTCC capabilities to execute research efforts involving molecular virology, eukaryotic genome editing, sequencing and bioinformatics, and/or the study of systems level virus-host interactions.
• Performs laboratory research on a wide range of viral agents that may include application of viral reverse genetics systems, analysis of viral and/or host gene or protein expressions, assessment of agent persistence in the environment, and assessment of virulence/pathogenesis of viral agents in animal models.
• Designs, implements, and leads virology related research projects aimed at addressing current biological threat characterization knowledge gaps, to include development of project plans, oversight of project teams, completion of deliverables within time and budget constraints, and compliance with all relevant regulatory and sponsor requirements.
• Prepares technical reports and proposals, presentation materials, safety plans, schedules and other programmatic documents prior to their submission ensuring that are high quality, accurate, and address the requirements of the sponsor.
• Maintains and awareness of scientific and programmatically-relevant trends, particularly those related to viral threat agents.
• Maintains accurate and complete records, compiles and accurately analyzes data, and present research results in written and oral formats clearly and concisely.
• Ability to effectively manage and prioritize multiple parallel laboratory activities and communicate the prioritization of these activities to stakeholders is essential.
• Ability to work effectively in a collaborative team environment where results are achieved through incorporation of multiple points of view.
• Exercises judgment within broadly defined practices and policies in selecting methods, techniques and evaluation criteria for obtaining results.
• Ability to formulate difficult science hypotheses and demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought, with the possibility to be a technical project lead on multiple projects.
• May determine methods and procedures on new assignments, while mentoring subordinates and/or technical personnel.
• Maintains a safe work environment by participating in specialized training and review of safety manuals and Standard Operating Procedures (SOPs).
• Identifies departures from the Quality Management System (QMS) and initiates actions to investigate and prevent such occurrences.
• Maintains and evaluates records of analysis and reviews laboratory results, plans and reports.
• Ensures that equipment, reagents and supplies are maintained and used properly.
• Directs, prioritizes, schedules and provides technical expertise to staff to conduct work.
• Maintains appropriate records.
• Performs other assigned duties.

BNBI is an Affirmative Action/Equal Opportunity Employer.
https://workforcenow.adp.com/mascsr/default/mdf/recruitment/recruitment.html?cid=2dbb865a-891f-4cfd-b874-312bc74233dd&ccId=19000101_000001&jobId=399905&source=CC2&lang=en_US

Filed Under: Jobs

NIDCD’s Research Supplements to Promote Diversity in Health-Related Research

February 11, 2021 by Rebecca Lopez


Please see the announcement below regarding NIDCD’s Research Supplements to Promote Diversity in Health-Related Research (https://grants.nih.gov/grants/guide/pa-files/PA-21-071.html):

“This is a great opportunity for participants from diverse backgrounds to join a research investigator funded by NIDCD. NIDCD’s investigators cover seven (7) research areas: hearing, balance, voice, speech, language, taste, and smell. Thus, there are multiple opportunities to participate in our research based on interests and future plans of a student or junior faculty member. Interested individuals can use the NIH Research Portfolio Online Reporting Tools (https://projectreporter.nih.gov/reporter.cfm) to learn more about NIDCD funded projects and investigators. Just search for NIDCD and enter research interest words. The Tool will provide the funded projects, name of the principal investigator(s),  institution, and state, and a summary of the project. It is a great way of matching research interests with NIDCD research!

NIDCD’s priority for participants in the diversity supplement program is predoctoral, postdoctoral, and faculty / early investigators (with little or no research experience or transitioning to new research fields). Per the announcement it is the institution who determines, justifies and confirms eligibility. Also, it is the principal investigator of the NIDCD-funded award who prepares the supplement application together with the candidate.”

If you have any questions, please reach out to:
Alberto L. Rivera-Rentas, Ph.D.
Research Training Officer
Division of Scientific Programs
Tel: (301) 496-1804
Fax: 301-402-0390
Email: riverara@nidcd.nih.gov

Learn more about NIDCD’s Pre-Doctoral Fellowships
NIDCD Research Training and Career Development Opportunities
National Institute on Deafness and Other Communications Disorders (NIDCD)

Image result for nidcd logo

Filed Under: Announcements Tagged With: National Institutes of Health

Penn Projects for Progress

February 9, 2021 by Rebecca Lopez


The Office of Social Equity & Community is pleased to announce the launch of Penn Projects for Progress, a fund and initiative established by President Amy Gutmann. The fund will support proposals designed to promote inclusion by focusing on one or more of the following:

  • Eradicating or reducing systemic racism
  • Achieving educational equity
  • Reducing health disparities based on race, gender, sexual orientation, and/or social determinants of health.

Projects must demonstrate how they will make a direct impact in Philadelphia, whether at Penn in particular or more broadly anywhere in the city. The projects will be conceived by teams of Penn students (undergraduate, graduate, and professional), staff, and faculty – learn more here and see our FAQ for details on eligibility.  

Deadline: 5PM EST on March 1, 2021. (Application goes live on February 15, 2021.) 

Filed Under: Announcements Tagged With: Science: Working Life

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