The FitzGerald lab has opportunities in its two areas of interest – bioactive lipids and the molecular clock.
In the first, current projects are focused on defining the role of eicosanoids and other bioactive lipids in cardiopulmonary disease, pain, the response to checkpoint blockade in cancer, aging and in viral infections, such as in COVID-19.
Our work on molecular clocks includes the integration of multi-omics and remote sensing data to define the human chronobiome in aging and in time dependent disease phenotypes such as non-dipping hypertension and asthma. We are also interested in the mechanisms which underlie sexual dimorphism in chronobiology and in using mass spec imaging and single cell biology to study circadian phenotypes in mice.
Overall, we are a group of around 30 from varied backgrounds including clinical medicine, informatics, mass spectrometry, genetics, metabolism, molecular and cell biology. A driving feature of our research is to integrate studies in model systems – mice, zebrafish, organoids, iPSC cells – with the deep and perturbed phenotyping possible in experimental medicine at the Center for Human Phenomic Science and the capacity to address hypotheses at scale using resources such as the Penn Medicine and UK Biobanks.
Please contact Garret FitzGerald (garret@upenn.edu).