Dr. Rothstein and Dr. Shlomchik at the University of Pittsburgh are looking for postdocs interested in studying Immunology:
Seeking a postdoctoral fellow to study the mechanisms whereby blood cancers escape and resist adoptive T cell immunotherapies. This newly R01-funded project employs mouse leukemias created from compound knockin/knockout mice. These leukemias will be CRISPR-edited to reveal critical pathways that govern resistance and sensitivity to T cell attack. Other techniques that will be employed include single cell RNA sequencing and analysis, the creation and use of novel T cell receptor knockin mice, high parameter flow cytometry and microscopy. Candidates will also gain experience in writing manuscripts and grants, along with oral presentations. A strong background in immunology or cancer biology and prior relevant mouse work is preferred. The University of Pittsburgh has strength in immunology, cancer immunology and systems immunology, making for a strong training environment. Interested candidates should email Warren Shlomchik at warrens@pitt.edu
LOOKING FOR IMMUNOLOGY POST-DOC to work on a new NIH-funded project on REGULATORY B CELLS A remarkably potent subset of ProB cells found in the bone marrow contains Breg precursors that can protect mice from autoimmunity (NOD, EAE) and prevent allograft rejection upon transfer of only ~50,000 cells to wild-type mice (Korniotis, Nat Commun 2016)!! This also provides the first ever evidence of a true Breg lineage. We wish to further characterize these cells and their progeny to identify genetic control of this lineage, their relationship to recently described TIM-1+ B cells (Xiao Cell reports 2020), and further identify their mechanism of action. Please email David Rothstein at rothsteind@upmc.edu
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