A postdoctoral research fellow position is available in the Ruggero lab at the University of California, San Francisco at the Helen Diller Comprehensive Cancer Center (Mission Bay Campus), to study the molecular mechanisms of post-transcriptional gene expression in health and disease. Several open questions in the lab include: how does oncogenic signaling remodel the ribosome and the translation machinery to drive cell growth and cellular transformation? What is the translational landscape of cancer cells during distinct steps of tumor evolution? What are the mechanisms in cis and trans for “onco-mRNA” translational selectivity?
The potential candidate will utilize mouse models for components of the translation machinery in combination with novel proteomics, ribosome-profiling, and pharmacological strategies to study the dynamics of translation control in gene expression, in normal and cancer cells. Highly motivated individuals with a recent Ph.D., M.D. or M.D./Ph.D. and a background in mouse genetics, biochemistry, or cellular and molecular biology are encouraged to apply. Evidence of scientific accomplishment is required and bioinformatics skills are desirable. Requests should be addressed to: Davide Ruggero (davide.ruggero@ucsf.edu) and Jane Jayme (krizlyjane.jayme@ucsf.edu).
Please visit our webpage at https://ruggerolab.ucsf.edu/.