Postdoctoral Research Fellow – The Children’s Hospital of Philadelphia

The Sabatino Laboratory at the Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Division of Hematology at The Children’s Hospital of Philadelphia (CHOP) is currently seeking a post-doctoral research fellow.  The laboratory focuses on gene therapy and the inherited bleeding disorder, hemophilia. The interests of the laboratory include (1) the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, (2) the development of gene-based therapeutic approaches for treating hemophilia and (3) understanding the immune response to factor VIII.  Current gene therapy strategies in the laboratory include adeno-associated viral (AAV) vector and lipid nanoparticle delivery approaches.  In addition, the laboratory is studying various aspects of gene therapy to understand the biology of gene transfer and the fate of the AAV vector DNA after gene delivery.

Interested applicants should contact Denise Sabatino, Ph.D. (dsabatin@pennmedicine.upenn.edu)