Rebecca Lopez

The Sabatino Laboratory at the Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Division of Hematology at The Children’s Hospital of Philadelphia (CHOP) is currently seeking a post-doctoral research fellow.  The laboratory focuses on gene therapy and the inherited bleeding disorder, hemophilia. The interests of the laboratory include (1) the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, (2) the development of gene-based therapeutic approaches for treating hemophilia and (3) understanding the immune response to factor VIII.  Current gene therapy strategies in the laboratory include adeno-associated viral (AAV) vector and lipid nanoparticle delivery approaches.  In addition, the laboratory is studying various aspects of gene therapy to understand the biology of gene transfer and the fate of the AAV vector DNA after gene delivery.

Interested applicants should contact Denise Sabatino, Ph.D. (dsabatin@pennmedicine.upenn.edu)

Dr. Rothstein and Dr. Shlomchik at the University of Pittsburgh are looking for postdocs interested in studying Immunology:

Seeking a postdoctoral fellow to study the mechanisms whereby blood cancers escape and resist adoptive T cell immunotherapies. This newly R01-funded project employs mouse leukemias created from compound knockin/knockout mice. These leukemias will be CRISPR-edited to reveal critical pathways that govern resistance and sensitivity to T cell attack. Other techniques that will be employed include single cell RNA sequencing and analysis, the creation and use of novel T cell receptor knockin mice, high parameter flow cytometry and microscopy. Candidates will also gain experience in writing manuscripts and grants, along with oral presentations. A strong background in immunology or cancer biology and prior relevant mouse work is preferred. The University of Pittsburgh has strength in immunology, cancer immunology and systems immunology, making for a strong training environment. Interested candidates should email Warren Shlomchik at warrens@pitt.edu

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LOOKING FOR IMMUNOLOGY POST-DOC to work on a new NIH-funded project on REGULATORY B CELLS A remarkably potent subset of ProB cells found in the bone marrow contains Breg precursors that can protect mice from autoimmunity (NOD, EAE) and prevent allograft rejection upon transfer of only ~50,000 cells to wild-type mice (Korniotis, Nat Commun 2016)!! This also provides the first ever evidence of a true Breg lineage. We wish to further characterize these cells and their progeny to identify genetic control of this lineage, their relationship to recently described TIM-1+ B cells (Xiao Cell reports 2020), and further identify their mechanism of action. Please email David Rothstein at rothsteind@upmc.edu

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